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Table 2 Sequences of dry-cured ham-derived dipeptides and tripeptides presenting bioactivity according to the BIOPEP database (access May 2019)

From: The relevance of dipeptides and tripeptides in the bioactivity and taste of dry-cured ham

   

Bioactivity

Peptide

Mass

Protein

ACE

Renin

DPP IV

Glucose uptake

Antioxidant

DPP III

sequencea

(Da)b

of originc

inhibitor

inhibitor

inhibitor

stimulating

activity

inhibitor

AA

160.17

MLC

x

 

x

   

AD

204.18

MLC, MHC

  

x

   

AG

146.14

MYOZ

x

 

x

   

AI

202.25

MLC

x

     

AKK

345.44

TTN

x

     

AL

202.25

MLC, CK

  

x

   

AP

186.21

MLC, TROP T

x

 

x

   

AT

190.20

MHC

  

x

   

AY

252.27

LDB3

x

 

x

 

x

 

EA

218.21

TTN, MYG

x

     

EAK

346.38

TTN

    

x

 

EF

278.35

UBQ

 

x

    

EI

260.29

TTN, TROP T

x

 

x

   

EK

275.30

MLC

x

 

x

   

EL

244.33

ENO

    

x

 

EP

244.25

TTN

  

x

   

GD

190.15

LDB3, CK

x

     

GK

203.24

MYG, MHC

x

     

GP

172.18

TTN

x

 

x

   

HK

283.33

MYG, CK

x

    

x

HP

252.27

CK

x

 

x

  

x

IE

260.29

MLC

x

     

II

244.33

ENO

  

x

x

  

IF

278.35

UBQ

x

     

IL

244.33

ENO

x

 

x

x

  

IM

262.37

CK

  

x

   

IN

245.28

MLC

  

x

   

IP

228.29

MHC, TROP T

x

 

x

   

IQ

259.30

CK, TROP T

  

x

   

KA

217.27

TTN, UBQ

x

 

x

  

x

KH

283.33

MYG

  

x

   

KP

243.30

TTN

x

 

x

 

x

 

KS

233.27

MHC

  

x

   

KT

247.29

MHC

  

x

   

KV

245.32

MLC, TTN

  

x

   

LA

202.25

CK

x

 

x

  

x

LG

188.23

MLC

x

     

LL

244.33

LDH

  

x

x

  

LQ

259.30

MHC

x

     

LR

287.36

MLC

x

x

   

x

LT

232.28

LDB3

  

x

   

MP

246.33

LDB3

  

x

   

NK

260.29

TROP T

x

     

NP

229.23

MLC, ENO

  

x

   

NR

289.29

CK

 

x

x

   

PA

186.21

MLC,TTN, LDB3

  

x

   

PAP

283.32

MLC

x

     

PE

244.25

MLC, TTN

     

x

PK

243.30

TTN

  

x

   

PL

228.29

CK

x

 

x

   

PP

212.25

TTN

x

 

x

   

QG

203.20

LDB3

x

 

x

   

QL

259.30

LDB3, MYG

  

x

   

QP

243.26

LDB3

  

x

   

RG

231.25

ENO

x

 

x

   

RL

287.36

LDB3

x

 

x

   

SG

162.14

MYOZ

x

     

SGP

259.26

MLC

x

     

SK

233.27

MYG

  

x

   

SV

204.22

TTN

  

x

   

TD

234.10

CK

  

x

   

TL

232.28

MHC

  

x

   

TN

233.22

MLC

  

x

   

TNP

330.34

MLC

x

     

TS

206.20

MHC

  

x

   

VE

246.26

TTN, CK

x

 

x

   

VF

264.32

MLC, CK

x

 

x

   

VH

254.29

TROP T

  

x

   

VK

245.32

MLC, TTN, GAPDH, MHC, UBQ

x

 

x

   

VQ

245.28

CK

  

x

   

VS

204.22

CK

  

x

   

VV

216.28

LDB3

  

x

   

VY

280.32

ENO

x

 

x

 

x

x

YV

280.32

CK

x

 

x

   
  1. Other bioactivities of the dipeptides. GP: antitrombotic, antiamnestic, and regulator of stomach mucosal membrane activity; EE: stimulating vasoactive substance release; EF: CaMPDE inhibition; LA: activating ubiquitin-mediated proteolysis
  2. aPeptide sequences are given as amino acids one-letter code
  3. bMass of the peptide sequence in Daltons calculated using PeptideMass from ExPASy
  4. cPossible proteins of origin of the peptides. Names of the abbreviated proteins are given in Table 1