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Table 2 Sequences of dry-cured ham-derived dipeptides and tripeptides presenting bioactivity according to the BIOPEP database (access May 2019)

From: The relevance of dipeptides and tripeptides in the bioactivity and taste of dry-cured ham

Peptide Mass Protein ACE Renin DPP IV Glucose uptake Antioxidant DPP III
sequencea (Da)b of originc inhibitor inhibitor inhibitor stimulating activity inhibitor
AA 160.17 MLC x   x    
AD 204.18 MLC, MHC    x    
AG 146.14 MYOZ x   x    
AI 202.25 MLC x      
AKK 345.44 TTN x      
AL 202.25 MLC, CK    x    
AP 186.21 MLC, TROP T x   x    
AT 190.20 MHC    x    
AY 252.27 LDB3 x   x   x  
EA 218.21 TTN, MYG x      
EAK 346.38 TTN      x  
EF 278.35 UBQ   x     
EI 260.29 TTN, TROP T x   x    
EK 275.30 MLC x   x    
EL 244.33 ENO      x  
EP 244.25 TTN    x    
GD 190.15 LDB3, CK x      
GK 203.24 MYG, MHC x      
GP 172.18 TTN x   x    
HK 283.33 MYG, CK x      x
HP 252.27 CK x   x    x
IE 260.29 MLC x      
II 244.33 ENO    x x   
IF 278.35 UBQ x      
IL 244.33 ENO x   x x   
IM 262.37 CK    x    
IN 245.28 MLC    x    
IP 228.29 MHC, TROP T x   x    
IQ 259.30 CK, TROP T    x    
KA 217.27 TTN, UBQ x   x    x
KH 283.33 MYG    x    
KP 243.30 TTN x   x   x  
KS 233.27 MHC    x    
KT 247.29 MHC    x    
KV 245.32 MLC, TTN    x    
LA 202.25 CK x   x    x
LG 188.23 MLC x      
LL 244.33 LDH    x x   
LQ 259.30 MHC x      
LR 287.36 MLC x x     x
LT 232.28 LDB3    x    
MP 246.33 LDB3    x    
NK 260.29 TROP T x      
NP 229.23 MLC, ENO    x    
NR 289.29 CK   x x    
PA 186.21 MLC,TTN, LDB3    x    
PAP 283.32 MLC x      
PE 244.25 MLC, TTN       x
PK 243.30 TTN    x    
PL 228.29 CK x   x    
PP 212.25 TTN x   x    
QG 203.20 LDB3 x   x    
QL 259.30 LDB3, MYG    x    
QP 243.26 LDB3    x    
RG 231.25 ENO x   x    
RL 287.36 LDB3 x   x    
SG 162.14 MYOZ x      
SGP 259.26 MLC x      
SK 233.27 MYG    x    
SV 204.22 TTN    x    
TD 234.10 CK    x    
TL 232.28 MHC    x    
TN 233.22 MLC    x    
TNP 330.34 MLC x      
TS 206.20 MHC    x    
VE 246.26 TTN, CK x   x    
VF 264.32 MLC, CK x   x    
VH 254.29 TROP T    x    
VK 245.32 MLC, TTN, GAPDH, MHC, UBQ x   x    
VQ 245.28 CK    x    
VS 204.22 CK    x    
VV 216.28 LDB3    x    
VY 280.32 ENO x   x   x x
YV 280.32 CK x   x    
  1. Other bioactivities of the dipeptides. GP: antitrombotic, antiamnestic, and regulator of stomach mucosal membrane activity; EE: stimulating vasoactive substance release; EF: CaMPDE inhibition; LA: activating ubiquitin-mediated proteolysis
  2. aPeptide sequences are given as amino acids one-letter code
  3. bMass of the peptide sequence in Daltons calculated using PeptideMass from ExPASy
  4. cPossible proteins of origin of the peptides. Names of the abbreviated proteins are given in Table 1