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Table 2 Brain/perfusion ratio of dipeptides in mouse perfusion experiments

From: A trip of peptides to the brain

Peptide log P Brain/Perfusate Ratio (μL/g-wet brain) Ki (μL/g-min)
FITC-albumin   6.46 ± 0.15 - 0.52 ± 0.50
Trp-Leu 1.623 no uptake -
Leu-Trp 1.019 no uptake -
Trp-Met 1.004 no uptake -
Trp-Tyr 0.212 no uptake -
Tyr-Pro 0.202 10.5 ± 1.3 3.53 ± 0.74
Ile-Tyr -0.249 no uptake -
Leu-Tyr -0.249 no uptake -
Pro-Tyr -0.398 no uptake -
His-Leu -0.477 no uptake -
Trp-His -0.555 no uptake -
Gly-Pro -0.602 10.85 ± 0.99 3.49 ± 0.66
Val-Tyr -0.758 no uptake -
His-Pro -0.881 no uptake -
Met-Tyr -0.888 no uptake -
Leu-Hisa -1.016 no uptake -
Tyr-Hisa -1.164 no uptake -
Tyr-Arga -1.269 no uptake -
Ser-Pro -1.634 no uptake -
Gly-Sar -1.651 24.54 ± 1.78 7.60 ± 1.29
Ser-Tyra -2.371 no uptake -
Ala-Gln -2.581 no uptake -
Ala-Glua -2.581 no uptake -
Ser-Hisa -3.139 no uptake -
  1. log P values are cited from SciFinder (https://scifinder.cas.org/scifinder/view/scifinder/scifinderExplore.jsf)
  2. no uptake : below the ratio of FITC-albumin of < 6.46 μL/g-wet brain (2 min) or 7.34 μL/g-wet brain (10 min)
  3. a10 min-perfusion