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Table 1 Parental proteins and main physicochemical characteristics attributed to the dipeptides of this study

From: Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase enzyme by dipeptides identified in dry-cured ham

Dipeptidea Dry-cured ham parental protein Net charge at pH 7 (value (pI))b Hydrophobicityc Steric hindrancec Main residue attribute (N-residue, C-residue)b
AA Myosin Light Chain 1
(Mora et al. 2019)
0 (3.69) 0.25 0.52 aliphatic, aliphatic
AL Myosin Light Chain 1
LIM domain-binding 3
(Mora et al. 2019)
0 (3.7) 0.39 0.53 aliphatic, aliphatic
AQ LIM domain-binding 3
(Mora et al. 2019)
0 (3.77) −0.22 0.60 aliphatic, polar
AW Nebulin (Kęska & Stadnik 2016)
(in silico)
0 (3.66) 0.31 0.51 aliphatic, aromatic
DA Myosin light chain isoforms (Zhou et al. 2020) −1 (0.69) −0.23 0.64 acidic, aliphatic
DD Sarcoplasmic & myofibrillar proteins (Kęska & Stadnik 2017)
(in silico)
−2 (0.73) −0.72 0.76 acidic, acidic
DG Sarcoplasmic & myofibrillar proteins
(Kęska & Stadnik 2017)
(in silico)
−1 (0.68) −0.28 0.72 acidic, aliphatic
EE Titin (Gallego et al. 2015)
Myosin light chain isoforms (Zhou et al. 2020)
−2 (0.85) −0.62 0.68 acidic, acidic
ES Sarcoplasmic & myofibrillar proteins
(Kęska & Stadnik 2017)
(in silico)
−1 (1.01) −0.44 0.60 acidic, polar
EV Sarcoplasmic & myofibrillar proteins
(Kęska & Stadnik 2017)
(in silico)
−1 (0.94) −0.04 0.69 acidic, aliphatic
GA   0 (3.63) 0.21 0.60 aliphatic, aliphatic
LE Sarcoplasmic & myofibrillar proteins
(Kęska & Stadnik 2017)
(in silico)
−1 (1) −0.04 0.60 aliphatic, acidic
LL Lactate dehydrogenase
(Mora et al. 2019)
0 (3.63) 0.53 0.53 aliphatic, aliphatic
PA LIM domain-binding 3
Myosin Light Chain 1
Titin (Mora et al. 2019)
0 (4.07) 0.09 0.44 aliphatic, aliphatic
QQ   0 (3.41) −0.69 0.68 polar,polar
VG Sarcoplasmic & myofibrillar proteins
(Kęska & Stadnik 2017)
(in silico)
0 (3.59) 0.35 0.69 aliphatic, aliphatic
VH Troponin T (Mora et al. 2016) 0.1 (7.78) 0.07 0.35 aliphatic, basic
  1. aPeptide sequences are given as amino acids one-letter code. bNet charges at pH 7, pI values, and main residue attribute obtained from PepCalc (https://pepcalc.com/) (access Nov 2020). cHydrophobicity and steric hindrance values obtained form ToxinPred (https://webs.iiitd.edu.in/raghava/toxinpred/multi_submitfreq_S.php?ran=22308) (access Nov 2020)