Fig. 2

Oral CBSF treatment improved the impaired endothelial-dependent relaxation (EDR) in db/db mouse aortae. Representative tracings (a) with summarized data (b-c) of EDR measured by wire myograph in isolated aortae from db/m⁺ and db/db mice with and without in vivo CBSF treatment (25 mg/kg/day). Summarized data of endothelium-independent relaxation of isolated aortae from db/m⁺ and db/db mice treated or non-treated with CBSF (d-e). Data are presented in mean ± SEM; n = 8, *p < 0.05 and **p < 0.01 relative to db/db. CBSF, crocodile blood soluble fraction; Phe, phenylephrine; ACh, acetylcholine; SNP, sodium nitroprusside