Fig. 3

Ex vivo CBSF incubation ameliorated the impaired EDR in db/db mouse aortae. EDR measured by wire myograph in non-treated db/m⁺ and db/db mice (a). Effect of ex vivo CBSF incubation on EDR in isolated aortae from non-treated db/db mice (b). Effect of ex vivo CBSF incubation on endothelium-independent relaxation in isolated aortae from non-treated db/m⁺ and db/db mice (c-d). Data are presented in means ± SEM; n = 3 for db/m+, n = 5 for db/db; *p < 0.05, **p < 0.01. CBSF, crocodile blood soluble fraction; Phe, phenylephrine; ACh, acetylcholine; SNP, sodium nitroprusside